Sandbox Reserved 1769: Difference between revisions

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=== Proline/Glycine Hinge ===

<scene name='95/952697/Ntcp_open-pore_state/40'>Glycine and proline residues</scene> in the <scene name='95/952697/Ntcp_open-pore_state/38'>connecting loops</scene> and <scene name='95/952697/Ntcp_open-pore_state/42'>extra- (ECH) and intracellular helices (ICH)</scene> (Figure 3) act as hinges between the <scene name='95/952697/Ntcp_open-pore_state/39'>open pore state</scene> and <scene name='95/952697/Ntcp_inward_facing_state/4'>inward-facing states</scene> in the mechanism of bile salt uptake. This flexibility allows separation of the core and panel domains, creating a pore open to the extracellular space and exposing critical Na+ binding sites. Once substrate binds the open-pore state, this hinge allows the transition to close this pore relative to the extracellular side and open to the cytoplasmic side, thus allowing release of substrate into the cell.<ref name = "Goutam" />

<scene name='95/952697/Ntcp_open-pore_state/40'>Glycine and proline residues</scene> in the <scene name='95/952697/Ntcp_open-pore_state/43'>connecting loops</scene> and <scene name='95/952697/Ntcp_open-pore_state/42'>extra- (ECH) and intracellular helices (ICH)</scene> (Figure 3) act as hinges between the <scene name='95/952697/Ntcp_open-pore_state/39'>open pore state</scene> and <scene name='95/952697/Ntcp_inward_facing_state/4'>inward-facing states</scene> in the mechanism of bile salt uptake. This flexibility allows separation of the core and panel domains, creating a pore open to the extracellular space and exposing critical Na+ binding sites. Once substrate binds the open-pore state, this hinge allows the transition to close this pore relative to the extracellular side and open to the cytoplasmic side, thus allowing release of substrate into the cell.<ref name = "Goutam" />

=== Sodium Binding Sites ===

Sandbox Reserved 1769: Difference between revisions

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@@ Line 18: / Line 18: @@
 === Proline/Glycine Hinge ===
-<scene name='95/952697/Ntcp_open-pore_state/40'>Glycine and proline residues</scene> in the <scene name='95/952697/Ntcp_open-pore_state/38'>connecting loops</scene> and <scene name='95/952697/Ntcp_open-pore_state/42'>extra- (ECH) and intracellular helices (ICH)</scene> (Figure 3) act as hinges between the <scene name='95/952697/Ntcp_open-pore_state/39'>open pore state</scene> and <scene name='95/952697/Ntcp_inward_facing_state/4'>inward-facing states</scene> in the mechanism of bile salt uptake. This flexibility allows separation of the core and panel domains, creating a pore open to the extracellular space and exposing critical Na+ binding sites. Once substrate binds the open-pore state, this hinge allows the transition to close this pore relative to the extracellular side and open to the cytoplasmic side, thus allowing release of substrate into the cell.<ref name = "Goutam" />
+<scene name='95/952697/Ntcp_open-pore_state/40'>Glycine and proline residues</scene> in the <scene name='95/952697/Ntcp_open-pore_state/43'>connecting loops</scene> and <scene name='95/952697/Ntcp_open-pore_state/42'>extra- (ECH) and intracellular helices (ICH)</scene> (Figure 3) act as hinges between the <scene name='95/952697/Ntcp_open-pore_state/39'>open pore state</scene> and <scene name='95/952697/Ntcp_inward_facing_state/4'>inward-facing states</scene> in the mechanism of bile salt uptake. This flexibility allows separation of the core and panel domains, creating a pore open to the extracellular space and exposing critical Na+ binding sites. Once substrate binds the open-pore state, this hinge allows the transition to close this pore relative to the extracellular side and open to the cytoplasmic side, thus allowing release of substrate into the cell.<ref name = "Goutam" />
 === Sodium Binding Sites ===