Sandbox Reserved 1777: Difference between revisions

<scene name='95/952706/Shoc2_mras_interaction/2'>MRAS binds to SHOC2</scene> exclusively through its concave LRRs<Ref name='Kwan'>Kwon, J.J., Hajian, B., Bian, Y. et al. Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex. Nature 609, 408–415 (2022).doi: 10.1038/s41586-022-04928-2. [https://doi.org/10.1038/s41586-022-04928-2. DOI:10.1038/s41586-022-04928-2] </Ref>, primarily by the descending loop and strands of LRR domains 2-10. '''Add his sentence thing''' <scene name='95/952706/Shoc2_pp1c_interaction/5'>PP1C binds</scene> with the ascending loops of the SHOC2 LRR regions, and is further engaged through the N-terminal region of SHOC2 which contains the <scene name='95/952706/Shoc2_rvxf/1'>RVxF motif</scene> <scene name='95/952706/Shoc2_rvxf/3'>RVxF motif 2</scene> <Ref name= 'Jajian'>Kwon, J., Jajian, B., Bian, Y. et al. Comprehensive structure-function evaluation of the SHOC2 holophosphatase reveals disease mechanisms and therapeutic opportunities. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022. [https://aacrjournals.org/cancerres/article/82/12_Supplement/LB029/699443. DOI: 10.1158/1538-7445.AM2022-LB029]. </Ref>. The initial forming of the complex begins with SHOC2-PP1C engagement, then is completed and stabilized by the GTP-loaded MRAS binding<Ref name="Jajian" />. Once associated with SHOC2, <scene name='95/952706/Mras_pp1c_interaction/5'>MRAS binds to PP1C</scene>. Binding to MRAS localizes the other two proteins to the RAS signaling regions of the membrane to begin cellular signaling<ref name="Kwan" />.