Sandbox Reserved 1777: Difference between revisions

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==SHOC2==

[[Image:SHOC2-PP1C-MRAS Surface.JPG|300px|right|thumb|<font size="2"><div style="text-align: center;">'''Figure 2'''. Surface representation of SHOC2-PP1C-MRAS ([https://www.rcsb.org/structure/7UPI PDB 7upi]). SHOC2 (blue), PP1C (orange) and MRAS (green). </div></font>]]

SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS <ref name="Hauseman" />, serving as an aggregation point to enable reciprocal interactions between these three signaling proteins. <scene name='95/952705/Shoc2_structure/2'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/9'>LRR motifs</scene> of <scene name='95/952705/Shoc2_structure/3'>~~Leucine~~ residues</scene>. LRR motifs form an extended β-sheet on the inner concave surface of SHOC2 with α-helices facing outward to facilitate binding of the protein complex. These LRR motifs result in a largely hydrophobic core within the concave region. <ref name="Hahn" />.

SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS <ref name="Hauseman" />, serving as an aggregation point to enable reciprocal interactions between these three signaling proteins. <scene name='95/952705/Shoc2_structure/2'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/9'>LRR motifs</scene> containing <scene name='95/952705/Shoc2_structure/3'>leucine residues</scene>. LRR motifs form an extended β-sheet on the inner concave surface of SHOC2 with α-helices facing outward to facilitate binding of the protein complex. These LRR motifs result in a largely hydrophobic core within the concave region. <ref name="Hahn" />.

==PP1C==

Sandbox Reserved 1777: Difference between revisions

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@@ Line 17: / Line 17: @@
 ==SHOC2==
 [[Image:SHOC2-PP1C-MRAS Surface.JPG|300px|right|thumb|<font size="2"><div style="text-align: center;">'''Figure 2'''. Surface representation of SHOC2-PP1C-MRAS ([https://www.rcsb.org/structure/7UPI PDB 7upi]). SHOC2 (blue), PP1C (orange) and MRAS (green).  </div></font>]]
-SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS <ref name="Hauseman" />, serving as an aggregation point to enable reciprocal interactions between these three signaling proteins. <scene name='95/952705/Shoc2_structure/2'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/9'>LRR motifs</scene> of <scene name='95/952705/Shoc2_structure/3'>Leucine residues</scene>. LRR motifs form an extended β-sheet on the inner concave surface of SHOC2 with α-helices facing outward to facilitate binding of the protein complex. These LRR motifs result in a largely hydrophobic core within the concave region. <ref name="Hahn" />.
+SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS <ref name="Hauseman" />, serving as an aggregation point to enable reciprocal interactions between these three signaling proteins. <scene name='95/952705/Shoc2_structure/2'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/9'>LRR motifs</scene> containing <scene name='95/952705/Shoc2_structure/3'>leucine residues</scene>. LRR motifs form an extended β-sheet on the inner concave surface of SHOC2 with α-helices facing outward to facilitate binding of the protein complex. These LRR motifs result in a largely hydrophobic core within the concave region. <ref name="Hahn" />.
 ==PP1C==