Sandbox Reserved 1777: Difference between revisions

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=Introduction=

SHOC2-PP1C-MRAS is a regulatory protein and enzyme complex that is involved in regulating cell proliferation and division <Ref name='Astrain'>Bernal Astrain G, Nikolova M, Smith MJ. Functional diversity in the RAS subfamily of small GTPases. Biochem Soc Trans. 2022 Apr 29;50(2):921-933. doi: 10.1042/BST20211166. [https://doi.org/10.1042/BST20211166. DOI:10.1042/BST20211166] </Ref>. This complex regulates the vast RAS-MAPK signaling pathway through control of the initial RAF MAPKKK. This pathway is initially activated by the binding of a growth factor to a [https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/. GTPase] which initiates intracellular RAS activation, such as ~~HRAS, NRAS, or KRAS.~~

SHOC2-PP1C-MRAS is a regulatory protein and enzyme complex that is involved in regulating cell proliferation and division <Ref name='Astrain'>Bernal Astrain G, Nikolova M, Smith MJ. Functional diversity in the RAS subfamily of small GTPases. Biochem Soc Trans. 2022 Apr 29;50(2):921-933. doi: 10.1042/BST20211166. [https://doi.org/10.1042/BST20211166. DOI:10.1042/BST20211166] </Ref>. This complex regulates the vast RAS-MAPK signaling pathway through control of the initial RAF MAPKKK. This pathway is initially activated by the binding of a growth factor to a [https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/. GTPase] which initiates intracellular RAS activation, such as

[https://www.frontiersin.org/articles/10.3389/fonc.2019.01088/full#:~:text=In%20human%20cells%2C%20three%20closely,proliferation%20and%20survival%20among%20others]. RAS-GTPases are a family of monomeric G-proteins that function as molecular switches and are key in regulating parts of signaling cascades. The RAS molecular switch alternates between binding GTP for the active state and GDP to become inactive <ref name="Astrain" />.

[https://www.frontiersin.org/articles/10.3389/fonc.2019.01088/full#:~:text=In%20human%20cells%2C%20three%20closely,proliferation%20and%20survival%20among%20others HRAS, NRAS, or KRAS]. RAS-GTPases are a family of monomeric G-proteins that function as molecular switches and are key in regulating parts of signaling cascades. The RAS molecular switch alternates between binding GTP for the active state and GDP to become inactive <ref name="Astrain" />.

[[Image:Screen Shot 2023-04-16 at 7.30.09 PM.jpeg|650px|thumb|<font size="2"><div style="text-align: center;">'''Figure 1'''. Schematic representation of RAS/RAF/MEK/ERK pathway after assembly of SHOC2-PP1C-MRAS complex. </div></font>]]

Sandbox Reserved 1777: Difference between revisions

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 <StructureSection load='7pui' size='350' side='right' caption='SHOC2-PP1C-MRAS (PDB entry [[7upi]])' scene='95/952704/Smpcolored/1'>
 =Introduction=
-SHOC2-PP1C-MRAS is a regulatory protein and enzyme complex that is involved in regulating cell proliferation and division <Ref name='Astrain'>Bernal Astrain G, Nikolova M, Smith MJ. Functional diversity in the RAS subfamily of small GTPases. Biochem Soc Trans. 2022 Apr 29;50(2):921-933. doi: 10.1042/BST20211166. [https://doi.org/10.1042/BST20211166. DOI:10.1042/BST20211166] </Ref>. This complex regulates the vast RAS-MAPK signaling pathway through control of the initial RAF MAPKKK. This pathway is initially activated by the binding of a growth factor to a [https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/. GTPase] which initiates intracellular RAS activation, such as HRAS, NRAS, or KRAS.
+SHOC2-PP1C-MRAS is a regulatory protein and enzyme complex that is involved in regulating cell proliferation and division <Ref name='Astrain'>Bernal Astrain G, Nikolova M, Smith MJ. Functional diversity in the RAS subfamily of small GTPases. Biochem Soc Trans. 2022 Apr 29;50(2):921-933. doi: 10.1042/BST20211166. [https://doi.org/10.1042/BST20211166. DOI:10.1042/BST20211166] </Ref>. This complex regulates the vast RAS-MAPK signaling pathway through control of the initial RAF MAPKKK. This pathway is initially activated by the binding of a growth factor to a [https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/. GTPase] which initiates intracellular RAS activation, such as
-[https://www.frontiersin.org/articles/10.3389/fonc.2019.01088/full#:~:text=In%20human%20cells%2C%20three%20closely,proliferation%20and%20survival%20among%20others]. RAS-GTPases are a family of monomeric G-proteins that function as molecular switches and are key in regulating parts of signaling cascades. The RAS molecular switch alternates between binding GTP for the active state and GDP to become inactive <ref name="Astrain" />.
+[https://www.frontiersin.org/articles/10.3389/fonc.2019.01088/full#:~:text=In%20human%20cells%2C%20three%20closely,proliferation%20and%20survival%20among%20others HRAS, NRAS, or KRAS]. RAS-GTPases are a family of monomeric G-proteins that function as molecular switches and are key in regulating parts of signaling cascades. The RAS molecular switch alternates between binding GTP for the active state and GDP to become inactive <ref name="Astrain" />.
 [[Image:Screen Shot 2023-04-16 at 7.30.09 PM.jpeg|650px|thumb|<font size="2"><div style="text-align: center;">'''Figure 1'''. Schematic representation of RAS/RAF/MEK/ERK pathway after assembly of SHOC2-PP1C-MRAS complex. </div></font>]]