Sandbox Reserved 1777: Difference between revisions
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{{Template:CH462_Biochemistry_II_2023}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Template:CH462_Biochemistry_II_2023}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
<StructureSection load='7pui' size='350' side='right' caption=''''SHOC2-PP1C-MRAS'''. SHOC2(blue) PP1C(orange) MRAS (green) (PDB entry [[7upi]])' scene='95/952704/Smpcolored/1'> | <StructureSection load='7pui' size='350' side='right' caption=''''SHOC2-PP1C-MRAS''''. SHOC2(blue) PP1C(orange) MRAS (green) (PDB entry [[7upi]])' scene='95/952704/Smpcolored/1'> | ||
=Introduction= | =Introduction= | ||
SHOC2-PP1C-MRAS is a regulatory protein and enzyme complex that is involved in regulating cell proliferation and division <Ref name='Astrain'>Bernal Astrain G, Nikolova M, Smith MJ. Functional diversity in the RAS subfamily of small GTPases. Biochem Soc Trans. 2022 Apr 29;50(2):921-933. doi: 10.1042/BST20211166. [https://doi.org/10.1042/BST20211166. DOI:10.1042/BST20211166] </Ref>. This complex regulates the vast RAS-MAPK signaling pathway through control of the initial RAF MAPKKK. This pathway is initially activated by the binding of a growth factor to a [https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/. GTPase] which initiates intracellular RAS activation, such as | SHOC2-PP1C-MRAS is a regulatory protein and enzyme complex that is involved in regulating cell proliferation and division <Ref name='Astrain'>Bernal Astrain G, Nikolova M, Smith MJ. Functional diversity in the RAS subfamily of small GTPases. Biochem Soc Trans. 2022 Apr 29;50(2):921-933. doi: 10.1042/BST20211166. [https://doi.org/10.1042/BST20211166. DOI:10.1042/BST20211166] </Ref>. This complex regulates the vast RAS-MAPK signaling pathway through control of the initial RAF MAPKKK. This pathway is initially activated by the binding of a growth factor to a [https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/. GTPase] which initiates intracellular RAS activation, such as | ||
