8in0: Difference between revisions
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==Structure of the Keap1 Kelch domain in complex with PGAM5-derived peptide== | |||
<StructureSection load='8in0' size='340' side='right'caption='[[8in0]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8in0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo Homo] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IN0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8in0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8in0 OCA], [https://pdbe.org/8in0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8in0 RCSB], [https://www.ebi.ac.uk/pdbsum/8in0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8in0 ProSAT]</span></td></tr> | ||
[[Category: Jiang | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Jiang L]] | |||
[[Category: Wang C]] | |||
Latest revision as of 13:15, 13 March 2024
Structure of the Keap1 Kelch domain in complex with PGAM5-derived peptide
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