1kkd: Difference between revisions

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[[Image:1kkd.gif|left|200px]]
{{Seed}}
[[Image:1kkd.png|left|200px]]


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{{STRUCTURE_1kkd|  PDB=1kkd  |  SCENE=  }}  
{{STRUCTURE_1kkd|  PDB=1kkd  |  SCENE=  }}  


'''Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)'''
===Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)===




==Overview==
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Small conductance Ca(2+)-activated potassium (SK) channels underlie the afterhyperpolarization that follows the action potential in many types of central neurons. SK channels are voltage-independent and gated solely by intracellular Ca(2+) in the submicromolar range. This high affinity for Ca(2+) results from Ca(2+)-independent association of the SK alpha-subunit with calmodulin (CaM), a property unique among the large family of potassium channels. Here we report the solution structure of the calmodulin binding domain (CaMBD, residues 396-487 in rat SK2) of SK channels using NMR spectroscopy. The CaMBD exhibits a helical region between residues 423-437, whereas the rest of the molecule lacks stable overall folding. Disruption of the helical domain abolishes constitutive association of CaMBD with Ca(2+)-free CaM, and results in SK channels that are no longer gated by Ca(2+). The results show that the Ca(2+)-independent CaM-CaMBD interaction, which is crucial for channel function, is at least in part determined by a region different in sequence and structure from other CaM-interacting proteins.
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{{ABSTRACT_PUBMED_11723128}}


==About this Structure==
==About this Structure==
1KKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKD OCA].  
1KKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKD OCA].  


==Reference==
==Reference==
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[[Category: Channel gating]]
[[Category: Channel gating]]
[[Category: Small-conductance calcium-activated potassium channel]]
[[Category: Small-conductance calcium-activated potassium channel]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:50:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:28:10 2008''

Revision as of 07:28, 2 July 2008

File:1kkd.png

Template:STRUCTURE 1kkd

Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)

Template:ABSTRACT PUBMED 11723128

About this Structure

1KKD is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin., Wissmann R, Bildl W, Neumann H, Rivard AF, Klocker N, Weitz D, Schulte U, Adelman JP, Bentrop D, Fakler B, J Biol Chem. 2002 Feb 8;277(6):4558-64. Epub 2001 Nov 26. PMID:11723128

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