Sandbox Reserved 1791: Difference between revisions

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== Introduction ==

[[Image:TSH system1.png|300 px|right|thumb| Figure 1: An overview of the Thyroid System. A depiction of signaling cascade from the hypothalamus ending in the release of TSH causing T3 and T4 production and its effects. The mechanism of regulation also shown by negative feedback from the T3 and T4 hormones. Source: [https://commons.wikimedia.org/wiki/File:Figure_37_04_01.png]]]

[[Image:TSH system1.png|300 px|right|thumb| Figure 1: An overview of the Thyroid System. A depiction of signaling cascade from the hypothalamus ending in the release of TSH causing T3 and T4 production and its effects. The mechanism of regulation is also shown by negative feedback from the T3 and T4 hormones. Source: [https://commons.wikimedia.org/wiki/File:Figure_37_04_01.png]]]

'''Thyroid Stimulating Hormone Receptor (TSHR)''' is a ~~type of~~ [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. It is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] ~~which is~~ known as thyrotropin. Activation of TSHR ~~is neccessary for activating~~ a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T3] and [https://en.wikipedia.org/wiki/Thyroid_hormones T4] (Fig 1).

'''Thyroid Stimulating Hormone Receptor (TSHR)''' is a [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. TSHR is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] also known as thyrotropin. Activation of TSHR initiates a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T3] and [https://en.wikipedia.org/wiki/Thyroid_hormones T4] (Fig 1). These hormones are used to regulate the metabolism.

== Structure==

TSHR forms a complex with TSH and Gs proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/1'>TSH-TSHR-Gs Complex</scene>.

Sandbox Reserved 1791: Difference between revisions

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 == Introduction ==
-[[Image:TSH system1.png|300 px|right|thumb| Figure 1: An overview of the Thyroid System. A depiction of signaling cascade from the hypothalamus ending in the release of TSH causing T3 and T4 production and its effects. The mechanism of regulation also shown by negative feedback from the T3 and T4 hormones. Source: [https://commons.wikimedia.org/wiki/File:Figure_37_04_01.png]]]
+[[Image:TSH system1.png|300 px|right|thumb| Figure 1: An overview of the Thyroid System. A depiction of signaling cascade from the hypothalamus ending in the release of TSH causing T3 and T4 production and its effects. The mechanism of regulation is also shown by negative feedback from the T3 and T4 hormones. Source: [https://commons.wikimedia.org/wiki/File:Figure_37_04_01.png]]]
-'''Thyroid Stimulating Hormone Receptor (TSHR)''' is a type of [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. It is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] which is known as thyrotropin. Activation of TSHR is neccessary for activating a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>] (Fig 1).
+'''Thyroid Stimulating Hormone Receptor (TSHR)''' is a [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. TSHR is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] also known as thyrotropin. Activation of TSHR initiates a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>] (Fig 1). These hormones are used to regulate the metabolism.
 == Structure==
 TSHR forms a complex with TSH and G<sub>s</sub> proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/1'>TSH-TSHR-Gs Complex</scene>.