Sandbox Reserved 1790: Difference between revisions
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===PP1C and MRAS=== | ===PP1C and MRAS=== | ||
[[Image: | [[Image:Hydro.jpg|500 px|thumb|'''Figure 1:'''Active site of PP1C on SMP.</div></font>]] | ||
The interactions between <scene name='95/952718/Mras_and_pp1c/1'>PP1C and MRAS</scene> are respectively mediated by four main <scene name='95/952716/Mras_and_pp1c/3'>polar interactions</scene>: ionic interactions are between D48-R188 and H53-D197, hydrogen bonds are between K36-Q198 and Q35-M190. As the complex forms, the active site for the dephosphorylation of RAF's S259 is oriented such that it remains accessible for RAF <ref name="Hauseman" />. The relative order of complex ordering is still an area of debate. Some experiments indicate that PP1C must bind to SHOC2 before MRAS binds<ref name="Lavoie" /> but others indicated that PP1C and MRAS can bind to SHOC2 at the same time <ref name="Hauseman" />. | The interactions between <scene name='95/952718/Mras_and_pp1c/1'>PP1C and MRAS</scene> are respectively mediated by four main <scene name='95/952716/Mras_and_pp1c/3'>polar interactions</scene>: ionic interactions are between D48-R188 and H53-D197, hydrogen bonds are between K36-Q198 and Q35-M190. As the complex forms, the active site for the dephosphorylation of RAF's S259 is oriented such that it remains accessible for RAF <ref name="Hauseman" />. The relative order of complex ordering is still an area of debate. Some experiments indicate that PP1C must bind to SHOC2 before MRAS binds<ref name="Lavoie" /> but others indicated that PP1C and MRAS can bind to SHOC2 at the same time <ref name="Hauseman" />. | ||
