Sandbox Reserved 1791: Difference between revisions
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== Introduction == | == Introduction == | ||
[[Image:TSH system1.png|300 px|right|thumb| Figure 1: An overview of the Thyroid System. A depiction of signaling cascade from the hypothalamus ending in the release of TSH causing T3 and T4 production and its effects. The mechanism of regulation is also shown by [https://biologydictionary.net/negative-feedback/ negative feedback] from the T3 and T4 hormones. Source: [https://commons.wikimedia.org/wiki/File:Figure_37_04_01.png]]] | [[Image:TSH system1.png|300 px|right|thumb| Figure 1: An overview of the Thyroid System. A depiction of signaling cascade from the hypothalamus ending in the release of TSH causing T3 and T4 production and its effects. The mechanism of regulation is also shown by [https://biologydictionary.net/negative-feedback/ negative feedback] from the T3 and T4 hormones. Source: [https://commons.wikimedia.org/wiki/File:Figure_37_04_01.png]]] | ||
'''Thyroid Stimulating Hormone Receptor (TSHR)''' is a [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles<ref name="Faust"> DOI 10.1038/s41586-022-05159-1</ref>. TSHR is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] also known as thyrotropin. Activation of TSHR initiates a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>] | '''Thyroid Stimulating Hormone Receptor (TSHR)''' is a [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles<ref name="Faust"> DOI 10.1038/s41586-022-05159-1</ref>. TSHR is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] also known as thyrotropin. Activation of TSHR initiates a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>] that are used to regulate the metabolism.(Fig 1) | ||
== Structure== | == Structure== | ||
TSHR forms an active signaling complex with TSH and G<sub>s</sub> proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/3'>TSH-TSHR-Gs Complex</scene>. TSH contains an α and a β subunit. The α subunit is a shared subunit amongst glycoproteins. The β subunit is unique to TSH. TSH binds to the extracellular domain of TSHR <ref name="Duan"> DOI 10.1038/s41586-022-05173-3</ref>. | TSHR forms an active signaling complex with TSH and G<sub>s</sub> proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/3'>TSH-TSHR-Gs Complex</scene>. TSH contains an α and a β subunit. The α subunit is a shared subunit amongst glycoproteins. The β subunit is unique to TSH. TSH binds to the extracellular domain of TSHR <ref name="Duan"> DOI 10.1038/s41586-022-05173-3</ref>. | ||
