8j0q: Difference between revisions

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'''Unreleased structure'''


The entry 8j0q is ON HOLD  until Paper Publication
==Structure of DNA binding domain of human TFAP2B==
 
<StructureSection load='8j0q' size='340' side='right'caption='[[8j0q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Liu, K., Xiao, Y.Q., Li, W.F., Min, J.R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8j0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J0Q FirstGlance]. <br>
Description: Structure of DNA binding domain of human TFAP2B
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Xiao, Y.Q]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j0q OCA], [https://pdbe.org/8j0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j0q RCSB], [https://www.ebi.ac.uk/pdbsum/8j0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j0q ProSAT]</span></td></tr>
[[Category: Min, J.R]]
</table>
[[Category: Li, W.F]]
== Disease ==
[[Category: Liu, K]]
[https://www.uniprot.org/uniprot/AP2B_HUMAN AP2B_HUMAN] Familial patent arterial duct;Char syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/AP2B_HUMAN AP2B_HUMAN] Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.<ref>PMID:11694877</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li WF]]
[[Category: Liu K]]
[[Category: Min JR]]
[[Category: Xiao YQ]]
Retrieved from "https://proteopedia.org/8j0q"