1kmk: Difference between revisions

Line 1:

[[Image:1kmk.~~gif~~|left|200px]]

[[Image:1kmk.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~E. coli NifS/CsdB protein at 2.20A with the cysteine perselenide intermediate (residue CSZ).~~'''~~

===E. coli NifS/CsdB protein at 2.20A with the cysteine perselenide intermediate (residue CSZ).===

~~==Overview==~~

<!--

~~E2 enzymes catalyze attachment of ubiquitin and ubiquitin~~-~~like proteins to lysine residues directly or through E3~~-~~mediated reactions.~~ The ~~small ubiquitin-like modifier SUMO regulates nuclear transport~~, ~~stress response~~, ~~and signal transduction in eukaryotes and is essential for cell-cycle progression in yeast. In contrast~~ to ~~most ubiquitin conjugation,~~ the SUMO E2 enzyme Ubc9 is sufficient for substrate recognition and lysine modification of known SUMO targets. Crystallographic analysis of a complex between mammalian Ubc9 and a C-terminal domain of RanGAP1 at 2.~~5 A reveals structural determinants for recognition of consensus SUMO modification sequences found within SUMO-conjugated proteins~~. ~~Structure-based mutagenesis and biochemical analysis of Ubc9 and RanGAP1 reveal distinct motifs required for substrate binding and SUMO modification of p53~~, ~~IkappaBalpha, and RanGAP1~~.

The line below this paragraph, {{ABSTRACT_PUBMED_11853669}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11853669 is the PubMed ID number.

-->

==About this Structure==

Line 32:

Line 36:

[[Category: Psi]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 22:55:07 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:33:39 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1kmk.gif|left|200px]]
+{{Seed}}
+[[Image:1kmk.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1kmk|  PDB=1kmk  |  SCENE=  }}
-'''E. coli NifS/CsdB protein at 2.20A with the cysteine perselenide intermediate (residue CSZ).'''
+===E. coli NifS/CsdB protein at 2.20A with the cysteine perselenide intermediate (residue CSZ).===
-==Overview==
+<!--
-E2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues directly or through E3-mediated reactions. The small ubiquitin-like modifier SUMO regulates nuclear transport, stress response, and signal transduction in eukaryotes and is essential for cell-cycle progression in yeast. In contrast to most ubiquitin conjugation, the SUMO E2 enzyme Ubc9 is sufficient for substrate recognition and lysine modification of known SUMO targets. Crystallographic analysis of a complex between mammalian Ubc9 and a C-terminal domain of RanGAP1 at 2.5 A reveals structural determinants for recognition of consensus SUMO modification sequences found within SUMO-conjugated proteins. Structure-based mutagenesis and biochemical analysis of Ubc9 and RanGAP1 reveal distinct motifs required for substrate binding and SUMO modification of p53, IkappaBalpha, and RanGAP1.
+The line below this paragraph, {{ABSTRACT_PUBMED_11853669}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11853669 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11853669}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Psi]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:55:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 10:33:39 2008''