1kn3: Difference between revisions

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[[Image:1kn3.gif|left|200px]]
{{Seed}}
[[Image:1kn3.png|left|200px]]


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{{STRUCTURE_1kn3|  PDB=1kn3  |  SCENE=  }}  
{{STRUCTURE_1kn3|  PDB=1kn3  |  SCENE=  }}  


'''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)'''
===Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)===




==Overview==
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Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.
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{{ABSTRACT_PUBMED_12037323}}


==About this Structure==
==About this Structure==
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[[Category: Phosphatidylethanolamine binding]]
[[Category: Phosphatidylethanolamine binding]]
[[Category: Raf-1 kinase inhibitor]]
[[Category: Raf-1 kinase inhibitor]]
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