Sandbox Reserved 1802: Difference between revisions
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Not much is known about the futalosine pathway and the way it works. MqnA is the first enzyme of the futalosine pathway catalyzing the dehydration of chorismate to yield 3-enolpyruvyl-benzoate (3-EPB), a reaction not observed for any other enzyme. Chorismate is the product of the shikimate pathway and the precursor of many aromatic compounds including the amino acids in addition to the electron carriers ubiquinone and menaquinone. As enzymes of the shikimate pathway, as well as enzymes that convert chorismate, are only present in bacteria, fungi, and plants, they are promising targets for antimicrobials and herbicides. | Not much is known about the futalosine pathway and the way it works. MqnA is the first enzyme of the futalosine pathway catalyzing the dehydration of chorismate to yield 3-enolpyruvyl-benzoate (3-EPB), a reaction not observed for any other enzyme. Chorismate is the product of the shikimate pathway and the precursor of many aromatic compounds including the amino acids in addition to the electron carriers ubiquinone and menaquinone. As enzymes of the shikimate pathway, as well as enzymes that convert chorismate, are only present in bacteria, fungi, and plants, they are promising targets for antimicrobials and herbicides. | ||
== Important amino acids== | == Important amino acids== | ||
The catalytic amino acids in my enzyme are ALA17, SER86, and PHE243. These three amino acids would be <scene name='95/954099/ | The catalytic amino acids in my enzyme are ALA17, SER86, and PHE243. These three amino acids would be considered the <scene name='95/954099/New_triad/2'>catalytic triad</scene>. | ||
ISJ (A) has the following Hydrogen bonds with ScMqnA: <scene name='95/954099/Hydrogen_bonds/3'>THR59, SER86, CYS87, SER109, ARG110, THR111, SER112, GLY151</scene> | ISJ (A) has the following Hydrogen bonds with ScMqnA: <scene name='95/954099/Hydrogen_bonds/3'>THR59, SER86, CYS87, SER109, ARG110, THR111, SER112, GLY151</scene> | ||
