7y61: Difference between revisions
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==Cryo-EM structure of the two CAF-1s bound right-handed Di-tetrasome== | |||
<StructureSection load='7y61' size='340' side='right'caption='[[7y61]], [[Resolution|resolution]] 5.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y61]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y61 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.6Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y61 OCA], [https://pdbe.org/7y61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y61 RCSB], [https://www.ebi.ac.uk/pdbsum/7y61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y61 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CAF1A_HUMAN CAF1A_HUMAN] Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.[UniProtKB:Q5R1T0] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Liu CP]] | |||
[[Category: Xu RM]] | |||
[[Category: Yu C]] | |||
[[Category: Yu ZY]] | |||
Latest revision as of 08:16, 16 August 2023
Cryo-EM structure of the two CAF-1s bound right-handed Di-tetrasome
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