8j7o: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "8j7o" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Human pyruvate carboxylase in BCCP-CTS state without BC== | |||
<StructureSection load='8j7o' size='340' side='right'caption='[[8j7o]], [[Resolution|resolution]] 3.83Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8j7o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J7O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.83Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTI:5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL'>BTI</scene></td></tr> | ||
[[Category: Liu | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j7o OCA], [https://pdbe.org/8j7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j7o RCSB], [https://www.ebi.ac.uk/pdbsum/8j7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j7o ProSAT]</span></td></tr> | ||
[[Category: Su | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:[https://omim.org/entry/266150 266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Liu DS]] | |||
[[Category: Su JY]] | |||
Revision as of 08:28, 9 May 2024
Human pyruvate carboxylase in BCCP-CTS state without BC
| ||||||||||||
