8oi2: Difference between revisions

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'''Unreleased structure'''


The entry 8oi2 is ON HOLD  until Paper Publication
==Crystal structure of Alb1 megabody in complex with human serum albumin==
 
<StructureSection load='8oi2' size='340' side='right'caption='[[8oi2]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors: De Felice, S., Zoia, G., Romanyuk, Z., Pardon, E., Steyaert, J., Angelini, A., Cendron, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8oi2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_G27 Helicobacter pylori G27] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OI2 FirstGlance]. <br>
Description: Crystal structure of Alb1 megabody in complex with human serum albumin
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oi2 OCA], [https://pdbe.org/8oi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oi2 RCSB], [https://www.ebi.ac.uk/pdbsum/8oi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oi2 ProSAT]</span></td></tr>
[[Category: Angelini, A]]
</table>
[[Category: De Felice, S]]
== Disease ==
[[Category: Steyaert, J]]
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
[[Category: Romanyuk, Z]]
== Function ==
[[Category: Cendron, L]]
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
[[Category: Pardon, E]]
== References ==
[[Category: Zoia, G]]
<references/>
__TOC__
</StructureSection>
[[Category: Helicobacter pylori G27]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Angelini A]]
[[Category: Cendron L]]
[[Category: De Felice S]]
[[Category: Pardon E]]
[[Category: Romanyuk Z]]
[[Category: Steyaert J]]
[[Category: Zoia G]]
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