8one: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 8one is ON HOLD until Paper Publication~~

==Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with Fe2+, Mn2+, UDP-Glucose==

~~Authors: Mattoteia, D., De Marco, M., Pinnola, A., Faravelli, S., Scietti, L., Forneris, F.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8one]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ONE OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8ONE FirstGlance].

~~Description:~~ Crystal Structure of full-length Human Lysyl Hydroxylase LH3 -Asp190Ser mutant -Cocrystal with Fe2+, Mn2+, UDP-Glucose

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>

[[Category: ~~Forneris, F~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8one FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8one OCA], [https://pdbe.org/8one PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8one RCSB], [https://www.ebi.ac.uk/pdbsum/8one PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8one ProSAT]</td></tr>

[[Category: ~~Scietti, L~~]]

</table>

[[Category: De Marco, M]]

== Disease ==

[[Category: Faravelli, S]]

[https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN] Connective tissue disorder due to lysyl hydroxylase-3 deficiency. The disease is caused by mutations affecting the gene represented in this entry.

[[Category: Mattoteia, D]]

== Function ==

[[Category: Pinnola, A]]

[https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN] Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.[UniProtKB:P24802]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: De Marco M]]

[[Category: Faravelli S]]

[[Category: Forneris F]]

[[Category: Mattoteia D]]

[[Category: Pinnola A]]

[[Category: Scietti L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8one is ON HOLD  until Paper Publication
+==Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with Fe2+, Mn2+, UDP-Glucose==
+<StructureSection load='8one' size='340' side='right'caption='[[8one]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Mattoteia, D., De Marco, M., Pinnola, A., Faravelli, S., Scietti, L., Forneris, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8one]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ONE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ONE FirstGlance]. <br>
-Description: Crystal Structure of full-length Human Lysyl Hydroxylase LH3 -Asp190Ser mutant -Cocrystal with Fe2+, Mn2+, UDP-Glucose
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
-[[Category: Forneris, F]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8one FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8one OCA], [https://pdbe.org/8one PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8one RCSB], [https://www.ebi.ac.uk/pdbsum/8one PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8one ProSAT]</span></td></tr>
-[[Category: Scietti, L]]
+</table>
-[[Category: De Marco, M]]
+== Disease ==
-[[Category: Faravelli, S]]
+[https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN] Connective tissue disorder due to lysyl hydroxylase-3 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
-[[Category: Mattoteia, D]]
+== Function ==
-[[Category: Pinnola, A]]
+[https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN] Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.[UniProtKB:P24802]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: De Marco M]]
+[[Category: Faravelli S]]
+[[Category: Forneris F]]
+[[Category: Mattoteia D]]
+[[Category: Pinnola A]]
+[[Category: Scietti L]]