8s90: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8s90 is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8s90]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S90 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8S90 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.73Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R2R:ruthenium(6+)+azanide+pentaamino(oxido)ruthenium+(1/4/2)'>R2R</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8s90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s90 OCA], [https://pdbe.org/8s90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s90 RCSB], [https://www.ebi.ac.uk/pdbsum/8s90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s90 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CAHM1_HUMAN CAHM1_HUMAN] Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (PubMed:18585350).[UniProtKB:D3Z291]<ref>PMID:18585350</ref> <ref>PMID:21574960</ref> <ref>PMID:22711817</ref> <ref>PMID:23300080</ref> <ref>PMID:23345406</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Furukawa H]]

[[Category: Syrjanen JL]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8s90 is ON HOLD  until Paper Publication
+==Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)==
+<StructureSection load='8s90' size='340' side='right'caption='[[8s90]], [[Resolution|resolution]] 4.73&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8s90]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S90 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.73&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R2R:ruthenium(6+)+azanide+pentaamino(oxido)ruthenium+(1/4/2)'>R2R</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s90 OCA], [https://pdbe.org/8s90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s90 RCSB], [https://www.ebi.ac.uk/pdbsum/8s90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s90 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CAHM1_HUMAN CAHM1_HUMAN] Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (PubMed:18585350).[UniProtKB:D3Z291]<ref>PMID:18585350</ref> <ref>PMID:21574960</ref> <ref>PMID:22711817</ref> <ref>PMID:23300080</ref> <ref>PMID:23345406</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Furukawa H]]
+[[Category: Syrjanen JL]]