1kp7: Difference between revisions

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[[Image:1kp7.gif|left|200px]]
{{Seed}}
[[Image:1kp7.png|left|200px]]


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{{STRUCTURE_1kp7|  PDB=1kp7  |  SCENE=  }}  
{{STRUCTURE_1kp7|  PDB=1kp7  |  SCENE=  }}  


'''Conserved RNA Structure within the HCV IRES eIF3 Binding Site'''
===Conserved RNA Structure within the HCV IRES eIF3 Binding Site===




==Overview==
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The hepatitis C virus (HCV) internal ribosome entry site (IRES) is recognized specifically by the small ribosomal subunit and eukaryotic initiation factor 3 (eIF3) before viral translation initiation. Using extensive mutagenesis and structure probing analysis, we show that the eIF3-binding domain of the HCV IRES contains an internal loop structure (loop IIIb) and an adjacent mismatched helix that are important for IRES-dependent initiation of translation. NMR studies reveal a unique three-dimensional structure for this internal loop that is conserved between viral isolates of varying primary sequence in this region. These data indicate that internal loop IIIb may be an attractive target for structure-based design of new antiviral agents.
The line below this paragraph, {{ABSTRACT_PUBMED_11927954}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11927954 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11927954}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP7 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP7 OCA].  


==Reference==
==Reference==
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[[Category: Ire]]
[[Category: Ire]]
[[Category: S-turn]]
[[Category: S-turn]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:00:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:41:33 2008''

Revision as of 07:41, 2 July 2008

File:1kp7.png

Template:STRUCTURE 1kp7

Conserved RNA Structure within the HCV IRES eIF3 Binding Site

Template:ABSTRACT PUBMED 11927954

About this Structure

Full experimental information is available from OCA.

Reference

A conserved RNA structure within the HCV IRES eIF3-binding site., Collier AJ, Gallego J, Klinck R, Cole PT, Harris SJ, Harrison GP, Aboul-Ela F, Varani G, Walker S, Nat Struct Biol. 2002 May;9(5):375-80. PMID:11927954

Page seeded by OCA on Wed Jul 2 10:41:33 2008

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