1jy1: Difference between revisions
New page: left|200px<br /> <applet load="1jy1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jy1, resolution 1.69Å" /> '''CRYSTAL STRUCTURE O... |
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'''CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1JY1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1JY1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY1 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: pld superfamily]] | [[Category: pld superfamily]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:10:18 2008'' | ||
Revision as of 14:10, 15 February 2008
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)
Overview
Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a, phosphodiester bond between a tyrosine residue and a DNA 3' phosphate. The, enzyme appears to be responsible for repairing the unique protein-DNA, linkage that occurs when eukaryotic topoisomerase I becomes stalled on the, DNA in the cell. The 1.69 A crystal structure reveals that human Tdp1 is a, monomer composed of two similar domains that are related by a, pseudo-2-fold axis of symmetry. Each domain contributes conserved, histidine, lysine, and asparagine residues to form a single active site., The structure of Tdp1 confirms that the protein has many similarities to, the members of the phospholipase D (PLD) superfamily and indicates a, similar catalytic mechanism. The structure also suggests how the unusual, protein-DNA substrate binds and provides insights about the nature of the, substrate in vivo.
Disease
Known disease associated with this structure: Spinocerebellar ataxia, autosomal recessive with axonal neuropathy OMIM:[607198]
About this Structure
1JY1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1., Davies DR, Interthal H, Champoux JJ, Hol WG, Structure. 2002 Feb;10(2):237-48. PMID:11839309
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