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==Free form of extended Cyp33-RRM==
==RNA binding induces an allosteric switch in Cyp33 to repress MLL1 mediated transcription regulation==
<StructureSection load='7zev' size='340' side='right'caption='[[7zev]]' scene=''>
<StructureSection load='7zev' size='340' side='right'caption='[[7zev]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7zev]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEV FirstGlance]. <br>
<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEV FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zev OCA], [https://pdbe.org/7zev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zev RCSB], [https://www.ebi.ac.uk/pdbsum/7zev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zev ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zev OCA], [https://pdbe.org/7zev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zev RCSB], [https://www.ebi.ac.uk/pdbsum/7zev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zev ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPIE_HUMAN PPIE_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mixed-lineage leukemia 1 (MLL1) is a transcription activator of the HOX family, which binds to specific epigenetic marks on histone H3 through its third plant homeodomain (PHD3) domain. Through an unknown mechanism, MLL1 activity is repressed by cyclophilin 33 (Cyp33), which binds to MLL1 PHD3. We determined solution structures of Cyp33 RNA recognition motif (RRM) free, bound to RNA, to MLL1 PHD3, and to both MLL1 and the histone H3 lysine N6-trimethylated. We found that a conserved alpha helix, amino-terminal to the RRM domain, adopts three different positions facilitating a cascade of binding events. These conformational changes are triggered by Cyp33 RNA binding and ultimately lead to MLL1 release from the histone mark. Together, our mechanistic findings rationalize how Cyp33 binding to MLL1 can switch chromatin to a transcriptional repressive state triggered by RNA binding as a negative feedback loop.
RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.,Blatter M, Meylan C, Clery A, Giambruno R, Nikolaev Y, Heidecker M, Solanki JA, Diaz MO, Gabellini D, Allain FH Sci Adv. 2023 Apr 21;9(16):eadf5330. doi: 10.1126/sciadv.adf5330. Epub 2023 Apr , 19. PMID:37075125<ref>PMID:37075125</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7zev" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allain F]]
[[Category: Allain F]]
[[Category: Blatter M]]
[[Category: Blatter M]]
[[Category: Meylan C]]
[[Category: Meylan C]]

Latest revision as of 06:23, 19 June 2024

RNA binding induces an allosteric switch in Cyp33 to repress MLL1 mediated transcription regulation

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