1kq2: Difference between revisions

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[[Image:1kq2.gif|left|200px]]
{{Seed}}
[[Image:1kq2.png|left|200px]]


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{{STRUCTURE_1kq2|  PDB=1kq2  |  SCENE=  }}  
{{STRUCTURE_1kq2|  PDB=1kq2  |  SCENE=  }}  


'''Crystal Structure of an Hfq-RNA Complex'''
===Crystal Structure of an Hfq-RNA Complex===




==Overview==
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In prokaryotes, Hfq regulates translation by modulating the structure of numerous RNA molecules by binding preferentially to A/U-rich sequences. To elucidate the mechanisms of target recognition and translation regulation by Hfq, we determined the crystal structures of the Staphylococcus aureus Hfq and an Hfq-RNA complex to 1.55 and 2.71 A resolution, respectively. The structures reveal that Hfq possesses the Sm-fold previously observed only in eukaryotes and archaea. However, unlike these heptameric Sm proteins, Hfq forms a homo-hexameric ring. The Hfq-RNA structure reveals that the single-stranded hepta-oligoribonucleotide binds in a circular conformation around a central basic cleft, whereby Tyr42 residues from adjacent subunits stack with six of the bases, and Gln8, outside the Sm motif, provides key protein-base contacts. Such binding suggests a mechanism for Hfq function.
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{{ABSTRACT_PUBMED_12093755}}


==About this Structure==
==About this Structure==
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[[Category: Single-stranded rna]]
[[Category: Single-stranded rna]]
[[Category: Translational regulator]]
[[Category: Translational regulator]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:01:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:44:41 2008''

Revision as of 07:44, 2 July 2008

File:1kq2.png

Template:STRUCTURE 1kq2

Crystal Structure of an Hfq-RNA Complex

Template:ABSTRACT PUBMED 12093755

About this Structure

1KQ2 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein., Schumacher MA, Pearson RF, Moller T, Valentin-Hansen P, Brennan RG, EMBO J. 2002 Jul 1;21(13):3546-56. PMID:12093755

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