8seq: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8seq is ~~ON HOLD until Paper Publication~~

==Cryo-EM Structure of RyR1 + AMP==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8seq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SEQ FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8seq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8seq OCA], [https://pdbe.org/8seq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8seq RCSB], [https://www.ebi.ac.uk/pdbsum/8seq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8seq ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Oryctolagus cuniculus]]

[[Category: Berezuk AM]]

[[Category: Cholak S]]

[[Category: Haji-Ghassemi O]]

[[Category: Saville JW]]

[[Category: Subramaniam S]]

[[Category: Tuttle KS]]

[[Category: Van Petegem F]]

[[Category: Zhu X]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8seq is ON HOLD  until Paper Publication
+==Cryo-EM Structure of RyR1 + AMP==
+<StructureSection load='8seq' size='340' side='right'caption='[[8seq]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8seq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SEQ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8seq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8seq OCA], [https://pdbe.org/8seq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8seq RCSB], [https://www.ebi.ac.uk/pdbsum/8seq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8seq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Oryctolagus cuniculus]]
+[[Category: Berezuk AM]]
+[[Category: Cholak S]]
+[[Category: Haji-Ghassemi O]]
+[[Category: Saville JW]]
+[[Category: Subramaniam S]]
+[[Category: Tuttle KS]]
+[[Category: Van Petegem F]]
+[[Category: Zhu X]]