4zk7: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zk7]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zk7]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk7 OCA], [https://pdbe.org/4zk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk7 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk7 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk7 OCA], [https://pdbe.org/4zk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk7 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/Q5SJY4_THET8 Q5SJY4_THET8]  
[https://www.uniprot.org/uniprot/Q5SJY4_THET8 Q5SJY4_THET8]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We recently reported the development of a computational method for the design of co-assembling, multi-component protein nanomaterials. While four such materials were validated at high-resolution by X-ray crystallography, low yield of soluble protein prevented X-ray structure determination of a fifth designed material, T33-09. Here we report the design and crystal structure of T33-31, a variant of T33-09 with improved soluble yield resulting from redesign efforts focused on mutating solvent-exposed side chains to charged amino acids. The structure is found to match the computational design model with atomic-level accuracy, providing further validation of the design approach and demonstrating a simple and potentially general means of improving the yield of designed protein nanomaterials. This article is protected by copyright. All rights reserved.
Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.,Bale JB, Park RU, Liu Y, Gonen S, Gonen T, Cascio D, King NP, Yeates TO, Baker D Protein Sci. 2015 Jul 15. doi: 10.1002/pro.2748. PMID:26174163<ref>PMID:26174163</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4zk7" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[CutA1 3D structures|CutA1 3D structures]]
*[[CutA1 3D structures|CutA1 3D structures]]
*[[3D structures of chorismate mutase|3D structures of chorismate mutase]]
*[[3D structures of chorismate mutase|3D structures of chorismate mutase]]
== References ==
<references/>
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</StructureSection>
</StructureSection>
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