1kuj: Difference between revisions

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[[Image:1kuj.gif|left|200px]]
{{Seed}}
[[Image:1kuj.png|left|200px]]


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{{STRUCTURE_1kuj|  PDB=1kuj  |  SCENE=  }}  
{{STRUCTURE_1kuj|  PDB=1kuj  |  SCENE=  }}  


'''Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose'''
===Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose===




==Overview==
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Evidence is presented that the specificity of jacalin, the seed lectin from jack fruit (Artocarpus integrifolia), is not directed exclusively against the T-antigen disaccharide Galbeta1,3GalNAc, lactose and galactose, but also against mannose and oligomannosides. Biochemical analyses based on surface-plasmon-resonance measurements, combined with the X-ray-crystallographic determination of the structure of a jacalin-alpha-methyl-mannose complex at 2 A resolution, demonstrated clearly that jacalin is fully capable of binding mannose. Besides mannose, jacalin also interacts readily with glucose, N-acetylneuraminic acid and N-acetylmuramic acid. Structural analyses demonstrated that the relatively large size of the carbohydrate-binding site enables jacalin to accommodate monosaccharides with different hydroxyl conformations and provided unambiguous evidence that the beta-prism structure of jacalin is a sufficiently flexible structural scaffold to confer different carbohydrate-binding specificities to a single lectin.
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{{ABSTRACT_PUBMED_11988090}}


==About this Structure==
==About this Structure==
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[[Category: Carbohydrate binding]]
[[Category: Carbohydrate binding]]
[[Category: Lectin]]
[[Category: Lectin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:11:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:01:49 2008''

Revision as of 08:01, 2 July 2008

File:1kuj.png

Template:STRUCTURE 1kuj

Crystal structure of Jacalin complexed with 1-O-methyl-alpha-D-mannose

Template:ABSTRACT PUBMED 11988090

About this Structure

1KUJ is a Protein complex structure of sequences from Artocarpus integer. Full crystallographic information is available from OCA.

Reference

Structural basis for the unusual carbohydrate-binding specificity of jacalin towards galactose and mannose., Bourne Y, Astoul CH, Zamboni V, Peumans WJ, Menu-Bouaouiche L, Van Damme EJ, Barre A, Rouge P, Biochem J. 2002 May 15;364(Pt 1):173-80. PMID:11988090

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