8j9q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8j9q is ~~ON HOLD until Paper Publication~~

==Crystal structure of UBR box of UBR4 apo==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8j9q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9Q OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8J9Q FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8j9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9q OCA], [https://pdbe.org/8j9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9q RCSB], [https://www.ebi.ac.uk/pdbsum/8j9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9q ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/UBR4_HUMAN UBR4_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.<ref>PMID:16214886</ref> <ref>PMID:23932781</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jeong D-E]]

[[Category: KIm S-J]]

[[Category: Shin H-C]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8j9q is ON HOLD  until Paper Publication
+==Crystal structure of UBR box of UBR4 apo==
+<StructureSection load='8j9q' size='340' side='right'caption='[[8j9q]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8j9q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J9Q FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9q OCA], [https://pdbe.org/8j9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9q RCSB], [https://www.ebi.ac.uk/pdbsum/8j9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBR4_HUMAN UBR4_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.<ref>PMID:16214886</ref> <ref>PMID:23932781</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jeong D-E]]
+[[Category: KIm S-J]]
+[[Category: Shin H-C]]