1ky6: Difference between revisions

Line 1:

[[Image:1ky6.~~jpg~~|left|200px]]

[[Image:1ky6.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE~~'''~~

===AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE===

~~==Overview==~~

<!--

~~Clathrin~~-~~mediated endocytosis depends upon the interaction of accessory proteins with the alpha~~-~~ear of~~ the ~~AP-2 adaptor. We present structural characterization of these regulatory interactions. DPF and DPW motif peptides derived from eps15 and epsin bind in type I beta turn conformations~~ to ~~a conserved pocket~~ on ~~the alpha-ear platform~~. ~~We show evidence for a second binding site that is DPW motif specific~~. ~~The structure of a complex with an AP-2 binding segment from amphiphysin reveals a novel binding motif that we term FxDxF~~, ~~which~~ is ~~engaged in an extended conformation by a unique surface of~~ the ~~platform domain~~. The FxDxF motif is also used by AP180 and the 170 kDa isoform of synaptojanin and can be found in several potential endocytic proteins, including HIP1, CD2AP, and PLAP. A mechanism of clathrin assembly regulation is suggested by three different AP-~~2 engagement modes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12057195}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12057195 is the PubMed ID number.

-->

==About this Structure==

Line 27:

Line 31:

[[Category: Endocytosis]]

[[Category: Protein-peptide complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 23:19:03 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:16:49 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ky6.jpg|left|200px]]
+{{Seed}}
+[[Image:1ky6.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ky6|  PDB=1ky6  |  SCENE=  }}
-'''AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE'''
+===AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE===
-==Overview==
+<!--
-Clathrin-mediated endocytosis depends upon the interaction of accessory proteins with the alpha-ear of the AP-2 adaptor. We present structural characterization of these regulatory interactions. DPF and DPW motif peptides derived from eps15 and epsin bind in type I beta turn conformations to a conserved pocket on the alpha-ear platform. We show evidence for a second binding site that is DPW motif specific. The structure of a complex with an AP-2 binding segment from amphiphysin reveals a novel binding motif that we term FxDxF, which is engaged in an extended conformation by a unique surface of the platform domain. The FxDxF motif is also used by AP180 and the 170 kDa isoform of synaptojanin and can be found in several potential endocytic proteins, including HIP1, CD2AP, and PLAP. A mechanism of clathrin assembly regulation is suggested by three different AP-2 engagement modes.
+The line below this paragraph, {{ABSTRACT_PUBMED_12057195}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12057195 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12057195}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Endocytosis]]
 [[Category: Protein-peptide complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:19:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 11:16:49 2008''