1kzf: Difference between revisions

Line 1:

[[Image:1kzf.~~gif~~|left|200px]]

[[Image:1kzf.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI~~'''~~

===Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI===

~~==Overview==~~

<!--

~~Synthesis and detection of acyl~~-~~homoserine lactones (AHLs) enables many gram~~-~~negative bacteria to engage in quorum sensing~~, an intercellular signaling mechanism that activates differentiation to virulent and biofilm lifestyles. The AHL synthases catalyze acylation of S-adenosyl-L-methionine by acyl-acyl carrier protein and lactonization of the ~~methionine moiety~~ to ~~give AHLs. The crystal structure of~~ the ~~AHL synthase, EsaI, determined~~ at 1.~~8 A resolution~~, ~~reveals a remarkable structural similarity to~~ the ~~N-acetyltransferases and defines a common phosphopantetheine binding fold as the catalytic core~~. ~~Critical residues responsible for catalysis and acyl chain specificity have been identified from a modeled substrate complex and verified through functional analysis in vivo. A mechanism for the N~~-~~acylation of S~~-~~adenosyl-L-methionine by 3-oxo-hexanoyl-acyl carrier protein is proposed.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11931774}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11931774 is the PubMed ID number.

-->

==About this Structure==

Line 32:

Line 36:

[[Category: Bacterial pathogenesis]]

[[Category: Quorum sensing]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 23:21:43 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:21:30 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1kzf.gif|left|200px]]
+{{Seed}}
+[[Image:1kzf.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1kzf|  PDB=1kzf  |  SCENE=  }}
-'''Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI'''
+===Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI===
-==Overview==
+<!--
-Synthesis and detection of acyl-homoserine lactones (AHLs) enables many gram-negative bacteria to engage in quorum sensing, an intercellular signaling mechanism that activates differentiation to virulent and biofilm lifestyles. The AHL synthases catalyze acylation of S-adenosyl-L-methionine by acyl-acyl carrier protein and lactonization of the methionine moiety to give AHLs. The crystal structure of the AHL synthase, EsaI, determined at 1.8 A resolution, reveals a remarkable structural similarity to the N-acetyltransferases and defines a common phosphopantetheine binding fold as the catalytic core. Critical residues responsible for catalysis and acyl chain specificity have been identified from a modeled substrate complex and verified through functional analysis in vivo. A mechanism for the N-acylation of S-adenosyl-L-methionine by 3-oxo-hexanoyl-acyl carrier protein is proposed.
+The line below this paragraph, {{ABSTRACT_PUBMED_11931774}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11931774 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11931774}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Bacterial pathogenesis]]
 [[Category: Quorum sensing]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:21:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 11:21:30 2008''