Alternate locations of backbones: Difference between revisions
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==AltLoc Backbone Cases== | ==AltLoc Backbone Cases== | ||
Case 1: TRIMCyp protein mediates innate immunity to HIV by inhibiting post-entry retrovirus replication. Evidence suggests that TRIMCyp has evolved through mutations to broaden the range of retroviruses it can inhibit<ref name="4dgd">PMID: 22407016</ref>. | Case 1: TRIMCyp protein mediates innate immunity to HIV by inhibiting post-entry retrovirus replication. Evidence suggests that TRIMCyp has evolved through mutations to broaden the range of retroviruses it can inhibit<ref name="4dgd">PMID: 22407016</ref>. These mutations render the active site able to assume multiple conformations. In particular, the cyclophilin-binding loop 64-74 (GGNFT HCNGT GG) exhibited flexibility<ref name="4dgd" />. | ||
==References== | ==References== | ||
<references /> | <references /> | ||
