1l2d: Difference between revisions

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[[Image:1l2d.gif|left|200px]]
{{Seed}}
[[Image:1l2d.png|left|200px]]


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{{STRUCTURE_1l2d|  PDB=1l2d  |  SCENE=  }}  
{{STRUCTURE_1l2d|  PDB=1l2d  |  SCENE=  }}  


'''MutM (Fpg)-DNA Estranged Guanine Mismatch Recognition Complex'''
===MutM (Fpg)-DNA Estranged Guanine Mismatch Recognition Complex===




==Overview==
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MutM is a bacterial 8-oxoguanine glycosylase responsible for initiating base-excision repair of oxidized guanine residues in DNA. Here we report five different crystal structures of MutM-DNA complexes that represent different steps of the repair reaction cascade catalyzed by the protein and also differ in the identity of the base opposite the lesion (the 'estranged' base). These structures reveal that the MutM active site performs the multiple steps of base-excision and 3' and 5' nicking with minimal rearrangement of the DNA backbone.
The line below this paragraph, {{ABSTRACT_PUBMED_12055620}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12055620 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12055620}}


==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:27:36 2008''
 
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