1l2e: Difference between revisions

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[[Image:1l2e.jpg|left|200px]]
{{Seed}}
[[Image:1l2e.png|left|200px]]


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{{STRUCTURE_1l2e|  PDB=1l2e  |  SCENE=  }}  
{{STRUCTURE_1l2e|  PDB=1l2e  |  SCENE=  }}  


'''Human Kallikrein 6 (hK6) Active Form with benzamidine inhibitor'''
===Human Kallikrein 6 (hK6) Active Form with benzamidine inhibitor===




==Overview==
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The human kallikreins are a large multigene family of closely related serine-type proteases. In this regard, they are similar to the multigene kallikrein families characterized in mice and rats. There is a much more extensive body of knowledge regarding the function of mouse and rat kallikreins in comparison with the human kallikreins. Human kallikrein 6 has been proposed as the homologue to rat myelencephalon-specific protease, an arginine-specific degradative-type protease abundantly expressed in the central nervous system and implicated in demyelinating disease. We present the x-ray crystal structure of mature, active recombinant human kallikrein 6 at 1.75-A resolution. This high resolution model provides the first three-dimensional view of one of the human kallikreins and one of only a few structures of serine proteases predominantly expressed in the central nervous system. Enzymatic data are presented that support the identification of human kallikrein 6 as the functional homologue of rat myelencephalon-specific protease and are corroborated by a molecular phylogenetic analysis. Furthermore, the x-ray data provide support for the characterization of human kallikrein 6 as a degradative protease with structural features more similar to trypsin than the regulatory kallikreins.
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{{ABSTRACT_PUBMED_11983703}}


==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Zyme]]
[[Category: Zyme]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:27:39 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:32:39 2008''

Revision as of 08:32, 2 July 2008

File:1l2e.png

Template:STRUCTURE 1l2e

Human Kallikrein 6 (hK6) Active Form with benzamidine inhibitor

Template:ABSTRACT PUBMED 11983703

About this Structure

1L2E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system., Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M, J Biol Chem. 2002 Jul 5;277(27):24562-70. Epub 2002 Apr 30. PMID:11983703

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