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| {{STRUCTURE_1l2k| PDB=1l2k | SCENE= }} | | {{STRUCTURE_1l2k| PDB=1l2k | SCENE= }} |
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| '''Neutron Structure Determination of Sperm Whale Met-Myoglobin at 1.5A Resolution.'''
| | ===Neutron Structure Determination of Sperm Whale Met-Myoglobin at 1.5A Resolution.=== |
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| ==Overview==
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| From the first days of protein neutron structure determination sperm whale myoglobin was an object under investigation [Nature 224 (1969) 143, J. Mol. Biol. 220 (1991) 381]. Nevertheless myoglobin is still of interest [Proc. Natl. Acad. Sci. USA 97 (2000) 3872]. The feasibility of the monochromatic neutron diffractometer BIX-3 at the JRR-3M reactor at the JAERI [J. Phys. Chem. Solids 60 (1999) 1623], to collect high-resolution diffraction data in a relatively short time stimulated us to repeat the structural determination of myoglobin. The structure of metmyoglobin has been determined up to a resolution of 1.5 A. The hydrogen atoms were replaced in part, by deuterium soaking the crystals for more than 10 years in D(2)O. A refinement of all atoms has been performed including the refinement of individual mean square displacements and occupancies of the exchangeable protons in backbone hydrogen bonds. A method is described to show clear negative scattering densities of the H atoms. Water molecules within the protein and on the molecule surface are shown. The exchangeability of H atoms is correlated with structural distribution and flexibility.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12062378}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12062378 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12062378}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Hydrogen atom]] | | [[Category: Hydrogen atom]] |
| [[Category: Neutron structure]] | | [[Category: Neutron structure]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:28:10 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:33:30 2008'' |
