1l3r: Difference between revisions

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[[Image:1l3r.gif|left|200px]]
{{Seed}}
[[Image:1l3r.png|left|200px]]


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{{STRUCTURE_1l3r|  PDB=1l3r  |  SCENE=  }}  
{{STRUCTURE_1l3r|  PDB=1l3r  |  SCENE=  }}  


'''Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase'''
===Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase===




==Overview==
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To understand the molecular mechanism underlying phosphoryl transfer of cAMP-dependent protein kinase, the structure of the catalytic subunit in complex with ADP, aluminum fluoride, Mg2+ ions and a substrate peptide was determined at 2.0 A resolution. Aluminum fluoride was modeled as AlF3 in a planar geometry; it is positioned 2.3 A from both the donor oxygen of ADP and the hydroxyl group of the recipient Ser residue. In this configuration, the aluminum atom forms a trigonal bipyramidal coordination with the oxygen atoms of the donor and recipient groups at the apical positions. This arrangement suggests that aluminum fluoride mimics the transition state and provides the first direct structural evidence for the in-line mechanism of phosphoryl transfer in a protein kinase.
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{{ABSTRACT_PUBMED_11896404}}


==About this Structure==
==About this Structure==
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[[Category: Protein-alf3 complex]]
[[Category: Protein-alf3 complex]]
[[Category: Transition state mimic]]
[[Category: Transition state mimic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:30:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:38:30 2008''

Revision as of 08:38, 2 July 2008

File:1l3r.png

Template:STRUCTURE 1l3r

Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase

Template:ABSTRACT PUBMED 11896404

About this Structure

1L3R is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase., Madhusudan, Akamine P, Xuong NH, Taylor SS, Nat Struct Biol. 2002 Apr;9(4):273-7. PMID:11896404

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