6y4h: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='6y4h' size='340' side='right'caption='[[6y4h]]' scene=''>
<StructureSection load='6y4h' size='340' side='right'caption='[[6y4h]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6y4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y4H FirstGlance]. <br>
<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y4H FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y4h OCA], [https://pdbe.org/6y4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y4h RCSB], [https://www.ebi.ac.uk/pdbsum/6y4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y4h ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y4h OCA], [https://pdbe.org/6y4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y4h RCSB], [https://www.ebi.ac.uk/pdbsum/6y4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y4h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9VSK3_DROME Q9VSK3_DROME]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which provide these proteins with a modular architecture. Accumulating evidence supports that RBP architectural modularity and adaptability define the specificity of their interactions with RNA. However, how multiple RBDs recognize their cognate single-stranded RNA (ssRNA) sequences in concert remains poorly understood. Here, we use Upstream of N-Ras (Unr) as a model system to address this question. Although reported to contain five ssRNA-binding cold-shock domains (CSDs), we demonstrate that Unr includes an additional four CSDs that do not bind RNA (pseudo-RBDs) but are involved in mediating RNA tertiary structure specificity by reducing the conformational heterogeneity of Unr. Disrupting the interactions between canonical and non-canonical CSDs impacts RNA binding, Unr-mediated translation regulation, and the Unr-dependent RNA interactome. Taken together, our studies reveal a new paradigm in protein-RNA recognition, where interactions between RBDs and pseudo-RBDs select RNA tertiary structures, influence RNP assembly, and define target specificity.
Pseudo-RNA-Binding Domains Mediate RNA Structure Specificity in Upstream of N-Ras.,Hollmann NM, Jagtap PKA, Masiewicz P, Guitart T, Simon B, Provaznik J, Stein F, Haberkant P, Sweetapple LJ, Villacorta L, Mooijman D, Benes V, Savitski MM, Gebauer F, Hennig J Cell Rep. 2020 Jul 21;32(3):107930. doi: 10.1016/j.celrep.2020.107930. PMID:32697992<ref>PMID:32697992</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6y4h" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hennig J]]
[[Category: Hennig J]]
[[Category: Hollmann NM]]
[[Category: Hollmann NM]]
[[Category: Simon B]]
[[Category: Simon B]]

Latest revision as of 06:09, 19 June 2024

Solution structure of cold-shock domain 7 and 8 of drosophila Upstream of N-Ras (Unr)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=6y4h&oldid=4184776"