6yeg: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6yeg]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_SPP1 Bacillus phage SPP1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YEG FirstGlance]. <br>
<table><tr><td colspan='2'>[[6yeg]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_SPP1 Bacillus phage SPP1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YEG FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yeg OCA], [https://pdbe.org/6yeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yeg RCSB], [https://www.ebi.ac.uk/pdbsum/6yeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yeg ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy , Hybrid , Solid-state NMR, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yeg OCA], [https://pdbe.org/6yeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yeg RCSB], [https://www.ebi.ac.uk/pdbsum/6yeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yeg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/TUBE_BPSPP TUBE_BPSPP] Forms the 160 nm long, sixfold helical, rigid tail tube. Binding to the entry receptor triggers structural rearrangements of the tail tube leading to ejection of the phage DNA into the host.<ref>PMID:17611601</ref> <ref>PMID:18786146</ref> <ref>PMID:25525268</ref> <ref>PMID:25991862</ref>  
[https://www.uniprot.org/uniprot/TUBE_BPSPP TUBE_BPSPP] Forms the 160 nm long, sixfold helical, rigid tail tube. Binding to the entry receptor triggers structural rearrangements of the tail tube leading to ejection of the phage DNA into the host.<ref>PMID:17611601</ref> <ref>PMID:18786146</ref> <ref>PMID:25525268</ref> <ref>PMID:25991862</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacteriophage SPP1 is a double-stranded DNA virus of the Siphoviridae family that infects the bacterium Bacillus subtilis. This family of phages features a long, flexible, non-contractile tail that has been difficult to characterize structurally. Here, we present the atomic structure of the tail tube of phage SPP1. Our hybrid structure is based on the integration of structural restraints from solid-state nuclear magnetic resonance (NMR) and a density map from cryo-EM. We show that the tail tube protein gp17.1 organizes into hexameric rings that are stacked by flexible linker domains and, thus, form a hollow flexible tube with a negatively charged lumen suitable for the transport of DNA. Additionally, we assess the dynamics of the system by combining relaxation measurements with variances in density maps.
Architecture of the flexible tail tube of bacteriophage SPP1.,Zinke M, Sachowsky KAA, Oster C, Zinn-Justin S, Ravelli R, Schroder GF, Habeck M, Lange A Nat Commun. 2020 Nov 13;11(1):5759. doi: 10.1038/s41467-020-19611-1. PMID:33188213<ref>PMID:33188213</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6yeg" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
Retrieved from "https://proteopedia.org/6yeg"