8j9a: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 8j9a is ON HOLD  until Paper Publication
==Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2==
 
<StructureSection load='8j9a' size='340' side='right'caption='[[8j9a]]' scene=''>
Authors: Zhang, H., Li, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8j9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J9A FirstGlance]. <br>
Description: Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9a OCA], [https://pdbe.org/8j9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9a RCSB], [https://www.ebi.ac.uk/pdbsum/8j9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9a ProSAT]</span></td></tr>
[[Category: Zhang, H]]
</table>
[[Category: Li, Y]]
== Function ==
[https://www.uniprot.org/uniprot/MED15_HUMAN MED15_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.<ref>PMID:12167862</ref> <ref>PMID:16630888</ref> <ref>PMID:16799563</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li Y]]
[[Category: Zhang H]]
Retrieved from "https://proteopedia.org/8j9a"