1lb2: Difference between revisions

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[[Image:1lb2.gif|left|200px]]
[[Image:1lb2.png|left|200px]]


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==Overview==
{{ABSTRACT_12202833}}
The Escherichia coli catabolite activator protein (CAP) activates transcription at P(lac), P(gal), and other promoters through interactions with the RNA polymerase alpha subunit carboxyl-terminal domain (alphaCTD). We determined the crystal structure of the CAP-alphaCTD-DNA complex at a resolution of 3.1 angstroms. CAP makes direct protein-protein interactions with alphaCTD, and alphaCTD makes direct protein-DNA interactions with the DNA segment adjacent to the DNA site for CAP. There are no large-scale conformational changes in CAP and alphaCTD, and the interface between CAP and alphaCTD is small. These findings are consistent with the proposal that activation involves a simple "recruitment" mechanism.


==About this Structure==
==About this Structure==
1LB2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1LB2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb48_1.html Catabolite Activator Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB2 OCA].  
1LB2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1LB2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb48_1.html Catabolite Activator Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB2 OCA].  
==Reference==
Structural basis of transcription activation: the CAP-alpha CTD-DNA complex., Benoff B, Yang H, Lawson CL, Parkinson G, Liu J, Blatter E, Ebright YW, Berman HM, Ebright RH, Science. 2002 Aug 30;297(5586):1562-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12202833 12202833]
[[Category: Catabolite Activator Protein]]
[[Category: Catabolite Activator Protein]]
[[Category: DNA-directed RNA polymerase]]
[[Category: DNA-directed RNA polymerase]]
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[[Category: Gene-regulatory]]
[[Category: Gene-regulatory]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:44:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:40:36 2008''

Revision as of 14:40, 26 June 2008

File:1lb2.png

Template:STRUCTURE 1lb2

Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA


Template:ABSTRACT 12202833

About this Structure

1LB2 is a Protein complex structure of sequences from Escherichia coli. The following page contains interesting information on the relation of 1LB2 with [Catabolite Activator Protein]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:40:36 2008

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