7ybf: Difference between revisions
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==Crystal structure of inner membrane protein Sad1 in complex with histone H2A-H2B== | |||
<StructureSection load='7ybf' size='340' side='right'caption='[[7ybf]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ybf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YBF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ybf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ybf OCA], [https://pdbe.org/7ybf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ybf RCSB], [https://www.ebi.ac.uk/pdbsum/7ybf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ybf ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H2B1_SCHPO H2B1_SCHPO] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[https://www.uniprot.org/uniprot/H2A2_SCHPO H2A2_SCHPO] Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:15226425</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Schizosaccharomyces pombe]] | |||
[[Category: Chen Y]] | |||
[[Category: Hu C]] | |||
[[Category: Sun W]] | |||
Revision as of 11:00, 3 January 2024
Crystal structure of inner membrane protein Sad1 in complex with histone H2A-H2B
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