8jfx: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8jfx is ~~ON HOLD until Paper Publication~~

==TruB domain of TruB1==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8jfx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JFX OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8JFX FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8jfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jfx OCA], [https://pdbe.org/8jfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jfx RCSB], [https://www.ebi.ac.uk/pdbsum/8jfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jfx ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TRUB1_HUMAN TRUB1_HUMAN] Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445).<ref>PMID:28073919</ref> <ref>PMID:31477916</ref> <ref>PMID:32926445</ref> <ref>PMID:33023933</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gong QG]]

[[Category: Xuan YM]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8jfx is ON HOLD  until Paper Publication
+==TruB domain of TruB1==
+<StructureSection load='8jfx' size='340' side='right'caption='[[8jfx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8jfx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JFX FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jfx OCA], [https://pdbe.org/8jfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jfx RCSB], [https://www.ebi.ac.uk/pdbsum/8jfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jfx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRUB1_HUMAN TRUB1_HUMAN] Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445).<ref>PMID:28073919</ref> <ref>PMID:31477916</ref> <ref>PMID:32926445</ref> <ref>PMID:33023933</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gong QG]]
+[[Category: Xuan YM]]