8p3t: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8p3t is ~~ON HOLD until Paper Publication~~

==Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8p3t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P3T FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p3t OCA], [https://pdbe.org/8p3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p3t RCSB], [https://www.ebi.ac.uk/pdbsum/8p3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p3t ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/GRIA1_RAT GRIA1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:16793768</ref> <ref>PMID:19265014</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Greger I]]

[[Category: Krieger J]]

[[Category: Yamashita K]]

[[Category: Zhang D]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8p3t is ON HOLD  until Paper Publication
+==Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1==
+<StructureSection load='8p3t' size='340' side='right'caption='[[8p3t]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8p3t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P3T FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p3t OCA], [https://pdbe.org/8p3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p3t RCSB], [https://www.ebi.ac.uk/pdbsum/8p3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p3t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GRIA1_RAT GRIA1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:16793768</ref> <ref>PMID:19265014</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Greger I]]
+[[Category: Krieger J]]
+[[Category: Yamashita K]]
+[[Category: Zhang D]]