1lc6: Difference between revisions

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[[Image:1lc6.gif|left|200px]]
{{Seed}}
[[Image:1lc6.png|left|200px]]


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{{STRUCTURE_1lc6|  PDB=1lc6  |  SCENE=  }}  
{{STRUCTURE_1lc6|  PDB=1lc6  |  SCENE=  }}  


'''Solution Structure of the U6 Intramolecular Stem-loop RNA'''
===Solution Structure of the U6 Intramolecular Stem-loop RNA===




==Overview==
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U6 RNA is a key component of the catalytic core of the spliceosome. A metal ion essential for the first catalytic step of pre-mRNA splicing binds to the U80 Sp phosphate oxygen within the yeast U6 intramolecular stem-loop (ISL). Here we present the first structural data for U6 RNA, revealing the three-dimensional structure of the highly conserved U6 ISL. The ISL binds metal ion at the U80 site with the same stereo specificity as the intact spliceosome. The metal-binding site is adjacent to a readily protonated C.A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing.
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{{ABSTRACT_PUBMED_11992125}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].  


==Reference==
==Reference==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Stem-loop]]
[[Category: Stem-loop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:46:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:19:13 2008''

Revision as of 09:19, 2 July 2008

File:1lc6.png

Template:STRUCTURE 1lc6

Solution Structure of the U6 Intramolecular Stem-loop RNA

Template:ABSTRACT PUBMED 11992125

About this Structure

Full experimental information is available from OCA.

Reference

Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:11992125

Page seeded by OCA on Wed Jul 2 12:19:13 2008

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