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| [[Image:1lcs.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1lcs| PDB=1lcs | SCENE= }} | | {{STRUCTURE_1lcs| PDB=1lcs | SCENE= }} |
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| '''RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS'''
| | ===RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS=== |
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| ==Overview==
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| Infection of T lymphocytes by the cytopathic retrovirus feline leukemia virus subgroup T (FeLV-T) requires FeLIX, a cellular coreceptor that is encoded by an endogenous provirus and closely resembles the receptor-binding domain (RBD) of feline leukemia virus subgroup B (FeLV-B). We determined the structure of FeLV-B RBD, which has FeLIX activity, to a 2.5-A resolution by X-ray crystallography. The structure of the receptor-specific subdomain of this glycoprotein differs dramatically from that of Friend murine leukemia virus (Fr-MLV), which binds a different cell surface receptor. Remarkably, we find that Fr-MLV RBD also activates FeLV-T infection of cells expressing the Fr-MLV receptor and that FeLV-B RBD is a competitive inhibitor of infection under these conditions. These studies suggest that FeLV-T infection relies on the following property of mammalian leukemia virus RBDs: the ability to couple interaction with one of a variety of receptors to the activation of a conserved membrane fusion mechanism. A comparison of the FeLV-B and Fr-MLV RBD structures illustrates how receptor-specific regions are linked to conserved elements critical for postbinding events in virus entry.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12552012}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12552012 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12552012}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Wensel, D L.]] | | [[Category: Wensel, D L.]] |
| [[Category: Antiparallel beta-sandwich glycoprotein]] | | [[Category: Antiparallel beta-sandwich glycoprotein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:47:38 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:23:16 2008'' |
