1ldp: Difference between revisions

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[[Image:1ldp.~~jpg~~|left|200px]]

[[Image:1ldp.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES~~'''~~

===CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES===

~~==Overview==~~

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~~MHC class I H~~-~~2Ld complexed with peptide QL9 (or p2Ca) is a high~~-~~affinity alloantigen for~~ the ~~2C TCR. We used~~ the ~~crystal structure of H-2Ld with a mixture of bound peptides~~ at ~~3.1 A to construct a model of the allogeneic 2C-Ld~~/~~QL9 complex for comparison with the syngeneic 2C-Kb~~/~~dEV8 structure~~. ~~A prominent ridge on the floor of the Ld peptide-binding groove, not present in Kb, creates a C-terminal bulge in Ld peptides that greatly increases interactions with the 2C beta-chain~~. ~~Furthermore~~, ~~weak electrostatic complementarity between Asp77 on the alpha1 helix of Kb and 2C~~ is ~~enhanced in~~ the ~~allogeneic complex by closer proximity of QL9 peptide residue AspP8 to the 2C HV4 loop~~.

The line below this paragraph, {{ABSTRACT_PUBMED_9620676}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9620676 is the PubMed ID number.

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==About this Structure==

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[[Category: Major histocompatibility complex]]

[[Category: Peptide antigen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 23:49:25 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:44:37 2008''

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-[[Image:1ldp.jpg|left|200px]]
+{{Seed}}
+[[Image:1ldp.png|left|200px]]
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 {{STRUCTURE_1ldp|  PDB=1ldp  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES'''
+===CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES===
-==Overview==
+<!--
-MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a mixture of bound peptides at 3.1 A to construct a model of the allogeneic 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure. A prominent ridge on the floor of the Ld peptide-binding groove, not present in Kb, creates a C-terminal bulge in Ld peptides that greatly increases interactions with the 2C beta-chain. Furthermore, weak electrostatic complementarity between Asp77 on the alpha1 helix of Kb and 2C is enhanced in the allogeneic complex by closer proximity of QL9 peptide residue AspP8 to the 2C HV4 loop.
+The line below this paragraph, {{ABSTRACT_PUBMED_9620676}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9620676 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9620676}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Major histocompatibility complex]]
 [[Category: Peptide antigen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:49:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 12:44:37 2008''