1le3: Difference between revisions

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[[Image:1le3.jpg|left|200px]]
{{Seed}}
[[Image:1le3.png|left|200px]]


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{{STRUCTURE_1le3|  PDB=1le3  |  SCENE=  }}  
{{STRUCTURE_1le3|  PDB=1le3  |  SCENE=  }}  


'''NMR Structure of Tryptophan Zipper 4: A Stable Beta-Hairpin Peptide Based on the C-terminal Hairpin of the B1 Domain of Protein G'''
===NMR Structure of Tryptophan Zipper 4: A Stable Beta-Hairpin Peptide Based on the C-terminal Hairpin of the B1 Domain of Protein G===




==Overview==
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A structural motif, the tryptophan zipper (trpzip), greatly stabilizes the beta-hairpin conformation in short peptides. Peptides (12 or 16 aa in length) with four different turn sequences are monomeric and fold cooperatively in water, as has been observed previously for some hairpin peptides. However, the folding free energies of the trpzips exceed substantially those of all previously reported beta-hairpins and even those of some larger designed proteins. NMR structures of three of the trpzip peptides reveal exceptionally well-defined beta-hairpin conformations stabilized by cross-strand pairs of indole rings. The trpzips are the smallest peptides to adopt an unique tertiary fold without requiring metal binding, unusual amino acids, or disulfide crosslinks.
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{{ABSTRACT_PUBMED_11331745}}


==About this Structure==
==About this Structure==
1LE3 is a [[Single protein]] structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hs0 1hs0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LE3 OCA].  
1LE3 is a [[Single protein]] structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hs0 1hs0]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LE3 OCA].  


==Reference==
==Reference==
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[[Category: Beta-hairpin]]
[[Category: Beta-hairpin]]
[[Category: Type i beta-turn]]
[[Category: Type i beta-turn]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:49:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:59:56 2008''