1lew: Difference between revisions

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[[Image:1lew.~~jpg~~|left|200px]]

[[Image:1lew.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A~~'''~~

===CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A===

~~==Overview==~~

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The ~~structures of the MAP kinase p38 in complex with docking site peptides containing a phi(A)-X-phi(B) motif~~, ~~derived from substrate MEF2A and activating enzyme MKK3b~~, ~~have been solved. The peptides bind~~ to the same site in the C-terminal domain of the kinase, which is both outside the active site and distinct from the "CD" domain previously implicated in docking site interactions. Mutational analysis on the interaction of p38 with the docking sites supports the crystallographic models and has uncovered two novel residues on ~~the docking groove that are critical for binding~~. ~~The two peptides induce similar large conformational changes local to the peptide binding groove~~. ~~The peptides also induce unexpected and different conformational changes in the active site~~, ~~as well as structural disorder in~~ the ~~phosphorylation lip~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12086621}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12086621 is the PubMed ID number.

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==About this Structure==

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[[Category: Serine/threonine-protein kinase]]

[[Category: Transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 23:51:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 16:13:04 2008''

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-[[Image:1lew.jpg|left|200px]]
+{{Seed}}
+[[Image:1lew.png|left|200px]]
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 {{STRUCTURE_1lew|  PDB=1lew  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A'''
+===CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A===
-==Overview==
+<!--
-The structures of the MAP kinase p38 in complex with docking site peptides containing a phi(A)-X-phi(B) motif, derived from substrate MEF2A and activating enzyme MKK3b, have been solved. The peptides bind to the same site in the C-terminal domain of the kinase, which is both outside the active site and distinct from the "CD" domain previously implicated in docking site interactions. Mutational analysis on the interaction of p38 with the docking sites supports the crystallographic models and has uncovered two novel residues on the docking groove that are critical for binding. The two peptides induce similar large conformational changes local to the peptide binding groove. The peptides also induce unexpected and different conformational changes in the active site, as well as structural disorder in the phosphorylation lip.
+The line below this paragraph, {{ABSTRACT_PUBMED_12086621}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12086621 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12086621}}
 ==About this Structure==
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 [[Category: Serine/threonine-protein kinase]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:51:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 16:13:04 2008''