5e5x: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5x OCA], [https://pdbe.org/5e5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5x RCSB], [https://www.ebi.ac.uk/pdbsum/5e5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5x OCA], [https://pdbe.org/5e5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5x RCSB], [https://www.ebi.ac.uk/pdbsum/5e5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5x ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register beta sheets, that may constitute one of the toxic species in aggregation related diseases. Here we sought to determine the presence of such a motif in Islet amyloid polypeptide (IAPP), whose amyloidogenic properties are associated with Type 2 Diabetes. We determined four new crystal structures of segments within IAPP all forming steric zippers. Most interestingly, one of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. Our results provide evidence that out-of-register beta sheets may be a common structural motif in amyloid aggregates and may be associated with toxicity.
Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.,Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D J Phys Chem B. 2015 Dec 2. PMID:26629790<ref>PMID:26629790</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5e5x" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 12:27, 6 March 2024

Structure of the amyloid forming peptide ANFLVH (residues 13-18) from islet amyloid polypeptide

5e5x, resolution 1.61Å

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