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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [https://pdbe.org/5e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [https://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [https://pdbe.org/5e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [https://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register beta sheets, that may constitute one of the toxic species in aggregation related diseases. Here we sought to determine the presence of such a motif in Islet amyloid polypeptide (IAPP), whose amyloidogenic properties are associated with Type 2 Diabetes. We determined four new crystal structures of segments within IAPP all forming steric zippers. Most interestingly, one of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. Our results provide evidence that out-of-register beta sheets may be a common structural motif in amyloid aggregates and may be associated with toxicity.
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| Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.,Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D J Phys Chem B. 2015 Dec 2. PMID:26629790<ref>PMID:26629790</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 5e61" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
