|
|
| Line 15: |
Line 15: |
| *NAD kinase | | *NAD kinase |
|
| |
|
| **[[3pfn]], [[7r4j]] – hNADK catalytic domain 61-442 – human<br /> | | **[[8kgc]], [[9cr3]] – hNADK 1-446 – human – Cryo EM<br /> |
| | **[[9cr4]] – hNADK 91-437 – Cryo EM<br /> |
| | **[[3pfn]], [[7r4j]] – hNADK catalytic domain 61-442 <br /> |
| **[[1u0r]], [[1u0t]] – MtNADK – ''Mycobacterium tuberculosis''<br /> | | **[[1u0r]], [[1u0t]] – MtNADK – ''Mycobacterium tuberculosis''<br /> |
| **[[1y3h]] – MtNADK (mutant)<br /> | | **[[1y3h]] – MtNADK (mutant)<br /> |
| Line 26: |
Line 28: |
| *NAD kinase complex | | *NAD kinase complex |
|
| |
|
| **[[7r4k]], [[7r4l]], [[7r4m]] – hNADK 2 catalytic domain + NADP<br /> | | **[[9cra]] – hNADK 91-437 + NAD – Cryo EM<br /> |
| | *[[7r4k]], [[7r4l]], [[7r4m]] – hNADK 2 catalytic domain + NADP<br /> |
| **[[7n29]] – hNADK 2 catalytic domain + NAD<br /> | | **[[7n29]] – hNADK 2 catalytic domain + NAD<br /> |
| **[[1y3i]] – MtNADK + NAD<br /> | | **[[1y3i]] – MtNADK + NAD<br /> |
| Line 40: |
Line 43: |
| **[[2i2f]] – LmNADK (mutant) + NAD + Pi<br /> | | **[[2i2f]] – LmNADK (mutant) + NAD + Pi<br /> |
| **[[5eji]] – LmNADK (mutant) + NADP + PPi<br /> | | **[[5eji]] – LmNADK (mutant) + NADP + PPi<br /> |
| | **[[8qg2]], [[8qg3]], [[8qg4]], [[8qg5]], [[8qg6]], [[8qg7]], [[8qg8]], [[8qg9]], [[8qga]], [[8qgb]], [[8qgc]], [[8qge]], [[8qgg]], [[8qgh]], [[8qgi]], [[8qgj]], [[8qgk]], [[8qgl]], [[8qgm]], [[8qgn]], [[8qgo]] – LmNADK 1 + di-adenosine derivative<br /> |
| **[[7mh7]], [[7qvs]] – NADK + NADP – ''Pseudomonas aeruginosa''<br /> | | **[[7mh7]], [[7qvs]] – NADK + NADP – ''Pseudomonas aeruginosa''<br /> |
| }} | | }} |
| Function
NAD kinase or ATP-dependent NAD kinase (NADK) catalyzes the conversion of ATP and NAD to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism[1]. See NAD and NAD(P)H.
Structural highlights
NADP is bound to NADK in a cleft between the N and C-terminal domains in the dimer interface[2]. Water molecules are shown as red spheres.
- ↑ Ohashi K, Kawai S, Murata K. Identification and characterization of a human mitochondrial NAD kinase. Nat Commun. 2012;3:1248. doi: 10.1038/ncomms2262. PMID:23212377 doi:https://dx.doi.org/10.1038/ncomms2262
- ↑ Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH. Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:16242716 doi:10.1016/j.jmb.2005.09.026
|
3D structures of NAD kinase
Updated on 15-January-2026
{"openlevels":0}
- NAD kinase
- NAD, NAD – hNADK 1-446 – human – Cryo EM
- NAD(P)H – hNADK 91-437 – Cryo EM
- 3pfn, 7r4j – hNADK catalytic domain 61-442
- 1u0r, 1u0t – MtNADK – Mycobacterium tuberculosis
- 1y3h – MtNADK (mutant)
- 1yt5 – NADK – Thermotoga maritima
- 2i1w – LmNADK – Listeria monocytogenes
- 5ejf, 5ejg, 5ejh – LmNADK (mutant)
- 4hao – NADK – Yersinia pestis
- 3pfn – NADK – human
- NAD kinase complex
- 9cra – hNADK 91-437 + NAD – Cryo EM
- 7r4k, 7r4l, 7r4m – hNADK 2 catalytic domain + NADP
- 7n29 – hNADK 2 catalytic domain + NAD
- 1y3i – MtNADK + NAD
- 1z0s – AfNADK + ATP + PPi – Archaeoglobus fulgidus
- 1z0u – AfNADK + NADP
- 1z0z – AfNADK + NAD
- 2i29 – LmNADK + NAD
- 2i2a – LmNADK + NADP
- 2i2b, 2i2c, 2i2d, 4dy6, 3v7u, 3v7w, 3v7y, 3v80, 3v8m, 3v8n, 3v8p, 5dhp, 5dhq, 5dhr, 5dhs, 5dht, 5dhu, 6z61, 6z64, 6z65, 7zz7, 7zz9, 7zza, 7zzb, 7zzc, 7zzd, 7zze, 7zzg, 7zzh, 7zzj, 8a9v, 8b47 – LmNADK + adenosine derivative inhibitor
- 2q5f, 3v8q, 3v8r – LmNADK (mutant) + adenosine derivative
- 6rbo, 6rbp, 6rbq, 6rbr, 6rbs, 6rbt, 6rbu, 6rbv, 6rbw, 6rbx, 6rby, 6rbz, 6rc0, 6rc1, 6rc2, 6rc3, 6rc4, 6rc5, 6rc6, 6rr2 – LmNADK + adenine derivative
- 6rg6, 6rg7, 6rg8, 6rg8, 6rg9, 6rga, 6rgb, 6rgc, 6rgd, 6rge, 6rgf – LmNADK + inhibitor
- 2i2f – LmNADK (mutant) + NAD + Pi
- 5eji – LmNADK (mutant) + NADP + PPi
- 8qg2, 8qg3, 8qg4, 8qg5, 8qg6, 8qg7, 8qg8, 8qg9, 8qga, 8qgb, 8qgc, 8qge, 8qgg, 8qgh, 8qgi, 8qgj, 8qgk, 8qgl, 8qgm, 8qgn, 8qgo – LmNADK 1 + di-adenosine derivative
- 7mh7, 7qvs – NADK + NADP – Pseudomonas aeruginosa
References
