8pb4: Difference between revisions
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==PsiM in complex with SAH and norbaeocystin, orthorhombic crystal form== | |||
<StructureSection load='8pb4' size='340' side='right'caption='[[8pb4]], [[Resolution|resolution]] 0.91Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8pb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Psilocybe_cubensis Psilocybe cubensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PB4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.91Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=XP6:Norbaeocystin'>XP6</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pb4 OCA], [https://pdbe.org/8pb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pb4 RCSB], [https://www.ebi.ac.uk/pdbsum/8pb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pb4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PSIM_PSICU PSIM_PSICU] N-methyltransferase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product (PubMed:28763571, PubMed:31150155). The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD (PubMed:28763571, PubMed:31150155). 4-hydroxy-L-tryptophan is accepted as substrate by psiD as well (PubMed:28763571). The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine (PubMed:28763571). The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin (PubMed:28763571, PubMed:31150155). The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin (PubMed:28763571, PubMed:31150155). 4-hydroxy-6-methyl-l-tryptophancan also be converted the decarboxylase PsiD, kinase PsiK, and methyltransferase PsiM into respectively 6-methyl-norbaeocystin, 6-methylbaeocystin, and 6-methylpsilocybin (PubMed:31150155).<ref>PMID:28763571</ref> <ref>PMID:31150155</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Psilocybe cubensis]] | |||
[[Category: Hudspeth J]] | |||
[[Category: Rupp B]] | |||
[[Category: Werten S]] | |||
Revision as of 05:49, 3 April 2024
PsiM in complex with SAH and norbaeocystin, orthorhombic crystal form
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